Valex-CR-500

Composition:

• Sodium Valproate 333 mg

• Valproic Acid 145 mg

Description:

Valex CR 500 is a controlled-release (CR) formulation of Sodium Valproate and Valproic Acid, designed to manage epilepsy, bipolar disorder, and migraines. It works by stabilizing electrical activity in the brain and enhancing the inhibitory neurotransmitter GABA, reducing seizures and mood swings.

Indications:

Valex CR 500 is prescribed for:

• Epilepsy:

  • Treats generalized seizures (tonic-clonic, myoclonic, absence seizures).

  • Manages focal (partial) seizures.

• Bipolar Disorder:

  • Helps stabilize mood swings and prevents manic episodes.

• Migraine Prevention:

  • Reduces frequency and severity of chronic migraines.

Mechanism of Action:

• Increases GABA (gamma-aminobutyric acid) levels in the brain.

• Suppresses excessive nerve activity, preventing seizures.

• Balances neurotransmitter levels, helping to regulate mood.

Key Benefits:

• Controlled-Release Formula: Provides a steady level of medication for long-lasting relief.

• Broad-Spectrum: Effective against multiple types of seizures.

• Dual Role: Manages both neurological and psychiatric conditions.

Dosage and Administration:

• Adults & Children (above 10 years): 500 mg – 1000 mg daily, adjusted by a doctor.

• Take with food to reduce stomach irritation.

• Swallow whole – do not crush or chew to maintain the extended-release effect.

Storage Instructions:

• Store below 30°C in a dry place.

• Keep away from direct sunlight and moisture.

• Keep out of reach of children.

Precautions:

• Liver Function: Regular liver enzyme tests are needed as valproate can cause liver damage.

• Pregnancy: Avoid unless absolutely necessary due to the risk of birth defects.

• Drug Interactions: Inform your doctor if taking:

  • Anticoagulants (blood thinners)

  • Other anticonvulsants

  • Alcohol (increases side effects and liver risk)

Caution:

• Drowsiness Warning: Avoid driving or using heavy machinery.

• Regular Blood Tests: Needed to monitor valproate levels.

Side Effects:

Common:

• Nausea, vomiting, stomach pain, drowsiness, tremors, weight changes.

Serious (Rare):

• Liver toxicity (jaundice, fatigue, abdominal pain).

• Pancreatitis (severe stomach pain, nausea, vomiting).

• Thrombocytopenia (low platelet count, increased bleeding risk).

• Neurological issues (headaches, dizziness, confusion).