Valex-CR-300

Composition:

• Sodium Valproate 200 mg

• Valproic Acid 87 mg

Description:

Valex CR 300 is an extended-release medication that combines Sodium Valproate and Valproic Acid. It is primarily used to control seizures in epilepsy, stabilize mood in bipolar disorder, and prevent migraines. The controlled-release (CR) formulation ensures a steady level of the drug in the bloodstream, reducing the need for frequent dosing and improving treatment compliance.

Indications:

Valex CR 300 is prescribed for:

• Epilepsy: Treats generalized and partial seizures in adults and children.

• Bipolar Disorder: Stabilizes mood swings and helps manage acute manic episodes.

• Migraine Prevention: Reduces the frequency and severity of migraines.

• Neuropathic Pain (Off-label): May be used for chronic nerve-related pain.

Benefits:

• Extended-Release Formula: Ensures steady drug levels for long-lasting effects.

• Dual Action: Combines Sodium Valproate and Valproic Acid for effective seizure and mood control.

• Reduces Seizures: Helps prevent both generalized and focal seizures.

• Mood Stabilizing: Reduces manic episodes in bipolar disorder.

• Convenient Dosing: Requires fewer doses per day due to controlled release.

Dosage and Administration:

• Epilepsy: 600 mg – 1200 mg daily, divided into 2-3 doses.

• Bipolar Disorder: 600 mg daily, with gradual adjustments as needed.

• Children: Dosage is based on body weight and should be prescribed by a doctor.

Instructions:

• Take with food to reduce stomach irritation.

• Swallow whole – do not crush or chew to maintain the extended-release effect.

• Follow your doctor’s dosage instructions carefully.

Storage Instructions:

• Store at 20°C to 25°C (68°F to 77°F).

• Keep in a tightly closed container to protect from moisture.

• Keep out of reach of children.

Precautions:

• Liver Function: Regular liver function tests are required as Valproate can cause hepatotoxicity.

• Pregnancy: Avoid use during pregnancy unless absolutely necessary due to the risk of birth defects.

• Alcohol: Avoid alcohol, as it can enhance sedative effects and increase the risk of liver damage.

• Kidney & Pancreatic Issues: Use with caution if you have a history of kidney disease or pancreatitis.

• Drug Interactions: Inform your doctor if taking:

  • Antiepileptic drugs

  • Blood thinners (anticoagulants)

  • Medications affecting liver enzymes

• Discontinuation: Reduce dose gradually to prevent withdrawal seizures.

Side Effects:

Common Side Effects:

• Nausea, vomiting, dizziness, drowsiness

• Mild tremors, headache, weight gain

• Fatigue, abdominal discomfort

Serious Side Effects (Rare):

• Liver damage (jaundice, severe fatigue, abdominal pain)

• Pancreatitis (severe stomach pain, nausea, vomiting)

• Blood disorders (bruising, unusual bleeding)

• Birth defects (if taken during pregnancy)